TAVR procedures can liberate embolic debris from the aortic valve and aorta during instrumentation. This debris can travel through the aortic arch and great vessels leading to the brain. Because blood vessels in the brain are small in size, debris can become lodged in the blood vessel, physically blocking blood flow. Lack of blood flow, called cerebral ischemia, can lead to brain injury – ranging from cognitive deficit (such as, problems with memory or decision-making) to stroke.